Description
Neurogranin is as a small protein encoded by the NRGN gene.
it is a calmodulin-binding protein expressed primarily in the brain, particularly in dendritic spines, and participating in the protein kinase C signaling pathway.
Neurogranin is the main postsynaptic protein regulating the availability of calmodulin, binding to it in the absence of calcium.
Phosphorylation by protein kinase C lowers its binding ability.
It is a potential biomarker of neurological and mental diseases